Listening After Nature questions the reality of auditory natures. It argues that the line between wilderness and industrial culture is dull, and the natural world is presently a critical construct that entangles humans, animals, sites and technologies. Bringing new insights to the field of environmental sound arts in areas such as field recording, acoustic ecology and soundscape studies, Wright examines contemporary and archival audio works and calls for a 'post-natural' approach to sound. The book propels sounds arts discourse into (...) critical relationship with the environmental humanities and contemporary approaches dealing with the consequences of Anthropogenic change. Critical and imaginative, this is a book that forges urgent debate between sound, ethics, aesthetics and ecology. (shrink)

The concepts of adaptation and fitness have such an appeal that they have been used in other scientific domains, including the social sciences. One particular aspect of this theory transfer concerns the so-called fitness landscape models. At first sight, fitness landscapes visualize how an agent, of any kind, relates to its environment, how its position is conditional because of the mutual interaction with other agents, and the potential routes towards improved fitness. The allure of fitness landscapes is first and foremost (...) that it represents a complex story about adaptation and fitness in one coherent image. Different accounts of fitness landscapes in different domains in the social sciences suggest that the properties and functions of fitness landscapes are attributed rather freely. These differences are testimony of the model’s versatility. At the same time, one will notice that the different approaches can also create ambiguity about the exact meaning and role of fitness landscapes in the social sciences. This article presents an extensive literature survey of the diverging interpretations and uses of fitness landscapes in the social sciences and discusses the implications in terms of how these models inform scientific inquiry. (shrink)

Wright’s “adaptive landscape” has been influential in evolutionary thinking but controversial, especially because the landscape that organisms encounter is altered by the evolutionary process itsel...

The phrase, "state of nature", has been used over centuries to describe the uncultivated state of lands and animals, nudity, innocence, heaven and hell, interstate relations, and the locus of pre- and supra-political rights, such as the right to resistance, to property, to create and leave polities, and the freedom of religion, speech, and opinion, which may be reactivated or reprioritised when the polity and its laws fail. Combining intellectual history with current concerns, this volume brings together fourteen essays on (...) the past, present and possible future applications of the legal fiction known as the state of nature. Contributors are: Daniel S. Allemann, Pamela Edwards, Ioannis D. Evrigenis, Mary C. Fuller, David Singh Grewal, Francesca Iurlaro, Edward J. Kolla, László Kontler, Grant S. McCall, Tom Sparks, Benjamin Straumann, Karl Widerquist, Sarah Winter, and Simone Zurbuchen. (shrink)

The author presents an historical account of scientific work conducted at a commercial biotech firm in San Diego called Hybritech. It tells of disruptions in research programs following the acquisition of the company by the pharmaceutical giant Eli Lilly in 1986. The story centers on responses to an organizational challenge that research managers and scientists in any setting, academic or industrial, must confront—how to create and sustain an organizational culture that is conducive to creativity and innovation. The case provides an (...) occasion for evaluating the strengths and weaknesses of two leading theoretical accounts of innovation in social studies of science and technology—sociological network analysis and actor-network theory. (shrink)

Frank Jackson and Robert Pargetter (1987)2 have argued for a version of reductive physicalism about color which they claim can accommodate the basic intuitions that have led others to embrace dispositionalism or subjectivism about color. Jackson (1996) has further developed the view and provided responses to some objections to its original statement. While Jackson and Pargetter do not have much company in endorsing their specific form of color physicalism, elements of their view have shown up in other realist accounts, including (...) the relativized account of color offered by John Spackman (2002), the disjunctivism of color properties endorsed by Peter Ross (2000), and the subjectivist strain present in Sydney Shoemaker’s (1994) discussion of color.3 Additionally, Mark Johnston (1992) has used Jackson and Pargetter’s view as a principal target in his arguments against color physicalism. (shrink)

There is considerable correspondence between theories and models used in biology and the social sciences. One type of model that is in use in both biology and the social sciences is the fitness landscape model. The properties of the fitness landscape model have been applied rather freely in the social domain. This is partly due to the versatility of the model, but it is also due to the difficulties of transferring a model to another domain. We will demonstrate that in (...) order to transfer the biological fitness landscape model to the social science it needs to be substantially modified. We argue that the syntactic structure of the model can remain unaltered, whilst the semantic dimension requires considerable modification in order to fit the specific phenomena in the social sciences. We will first discuss the origin as well as the basic properties of the model. Subsequently, we will demonstrate the considerations and modifications pertaining to such a transfer by showing how and why we altered the model to analyse collective decision-making processes. We will demonstrate that the properties of the target domain allow for a transfer of the syntactic structure but don’t tolerate the semantic transfer. (shrink)

With his recent introduction of `posthumanism, " a decentered variant of constructivist sociology of science, Andrew Pickering advertises novel conceptual resources for social theorists. In fact, he tenders nothing less than a fundamental reordering of social thought. By invoking the concept of "material agency, " Pickering seeks to redefine the relationship between "Nature" and "Society," while dismissing the "humanist bias" inherent in sociological inquiry. However, for all its ambition and good intentions, posthumanism delivers only analytical inconsistencies, the consequences of an (...) uneasy synthesis of pragmatist and poststructuralist influences. When translated into the language of conventional sociological theory, these problems surface as an inadequate treatment of human agency. The works of the original pragmatists, particularly C.S. Peirce and G.H. Mead, illustrate how the objectives of posthumanism can be achieved without decentering, suggesting a renewed appreciation of "humanist" sociologies. (shrink)

A principal goal of this book is to develop and apply the Situation Semantics framework. Jean Mark Gawron and Stanley Peters adopt a version of the theory in which meanings are built up via syntactically driven semantic composition rules. They provide a substantial treatment of English incorporating treatments of pronomial anaphora, quantification, donkey anaphora, and tense. The book focuses on the semantics of pronomial anaphora and quantification. The authors argue that the ambiguities of sentences with pronouns cannot be adequately (...) accounted for with a theory that represents anaphoric relations only syntactically; their relational framework uniformly deals with anaphoric relations as relations between utterances in context. They argue that there is no need for a syntactic representation of anaphoric relations, or for a theory that accounts for anaphoric ambiguities by resorting to two or more kinds of anaphora. Quantifier scope ambiguities are handled analogously to anaphoric ambiguities. This treatment integrates the Cooper Store mechanism with a theory of meaning that provides both a natural setting for it and a convincing account of what, semantically, is going on. Jean Mark Gawron is a researcher for Hewlett Packard Laboratories, Palo Alto. Stanley Peters is professor of linguistics and symbolic systems at Stanford University and is director of the Center for the Study of Language and Information. (shrink)

Deaths of Despair (DoD), or mortality resulting from suicide, drug overdose, and alcohol-related liver disease, have been rising steadily in the United States over the last several decades. In 2020, a record 186,763 annual despair-related deaths were documented, contributing to the longest sustained decline in US life expectancy since 1915–1918. This forum feature considers how health humanities disciplines might fruitfully engage with this era-defining public health catastrophe and help society better understand and respond to the crisis.

Shoshana Zuboff’s international bestseller, The Age of Surveillance Capitalism: The Fight for a Human Future at the New Frontier of Power, was reviewed in the Wall Street Journal as a book that asks us ‘to pause long enough to think about the future and how it might be different from today.’ That description could work as the definition of the literary utopia or dystopia. In fact, Zuboff’s book has consecutive chapters titled ‘Big Other and the Rise of Instrumentalist Power’ and (...) ‘A Utopia of Certainty’. In the former chapter, the title of which seems to reference George Orwell’s Nineteen Eighty-Four, Zuboff argues that there now exists a ‘ubiquitous digital apparatus’ that ‘renders, monitors, computes and modifies human behaviour’. In the latter chapter she asserts that the ‘surveillance capitalist leaders [such as Mark Zuckerberg and Larry Page, CEOs of Facebook and Google respectively] are sui generis utopianists’. This article critically assesses Zuboff’s claims in relation to Dave Eggers’ 2013 novel The Circle, where the eponymous utopian/dystopian company’s name, as well its motto ‘ALL THAT HAPPENS MUST BE KNOWN’ gesture towards Jeremy Bentham’s panopticon writings. This article explores Zuboff’s factual and Eggers’ fictional examinations of surveillance capitalism. While Zuboff’s and Eggers’ works have different points of departure and modes of representation, a comparative reading suggests key points of overlap and disagreement about the impact of surveillance in the contemporary world, about what the future might hold, and about how we should respond. (shrink)

There are no national recommendations for routine screening for sickle cell trait, nor is there guidance on whether or how to notify donors that they might be tested or identified as having sickle cell trait. As a result, the organizations that collect blood have implemented variable policies about whether and how to inform prospective donors of the possible screening and discovery of this noncommunicable condition. The question of what they should do is related to the broader question of how to (...) handle incidental and secondary findings. In a recent report, the Presidential Commission for the Study of Bioethical Issues outline a framework for handling such findings in the clinical, research, and direct‐to‐consumer contexts. While the commission's report did not directly address incidental and secondary findings in the public health context of blood donation, it made several overarching recommendations that apply in all contexts where such findings might arise. This essay outlines the special issues raised by discovering sickle cell trait in blood donation and considers the implications of the commission's framework for that problem. (shrink)

In this paper we examine Fehr’s notions of “altruism”, “strong reciprocity” and “altruistic punishment” and query his ascription of altruism. We suggest that, pace Fehr, altruism cannot be defined behaviourally because the definition of altruism must refer to the motives of actors. We also advert to certain inconsistencies in Fehr’s usage of his terms and we question his explanation of altruism in terms of ‘social preferences’.

YouTube has been implicated in the transformation of users into extremists and conspiracy theorists. The alleged mechanism for this radicalizing process is YouTube’s recommender system, which is optimized to amplify and promote clips that users are likely to watch through to the end. YouTube optimizes for watch-through for economic reasons: people who watch a video through to the end are likely to then watch the next recommended video as well, which means that more advertisements can be served to them. This (...) is a seemingly innocuous design choice, but it has a troubling side-effect. Critics of YouTube have alleged that the recommender system tends to recommend extremist content and conspiracy theories, as such videos are especially likely to capture and keep users’ attention. To date, the problem of radicalization via the YouTube recommender system has been a matter of speculation. The current study represents the first systematic, pre-registered attempt to establish whether and to what extent the recommender system tends to promote such content. We begin by contextualizing our study in the framework of technological seduction. Next, we explain our methodology. After that, we present our results, which are consistent with the radicalization hypothesis. Finally, we discuss our findings, as well as directions for future research and recommendations for users, industry, and policy-makers. (shrink)

This volume in the prestigious series of Oxford Handbooks provides a widely accessible overview of legal scholarship at the start of the 21st century. Through 43 essays by leading legal scholars based in the USA, the UK, Australia, New Zealand, Canada and Germany, it offers original and interpretative accounts of the nature, themes and trends of research and writing about all areas of the law.

YouTube has been implicated in the transformation of users into extremists and conspiracy theorists. The alleged mechanism for this radicalizing process is YouTube’s recommender system, which is optimized to amplify and promote clips that users are likely to watch through to the end. YouTube optimizes for watch-through for economic reasons: people who watch a video through to the end are likely to then watch the next recommended video as well, which means that more advertisements can be served to them. This (...) is a seemingly innocuous design choice, but it has a troubling side-effect. Critics of YouTube have alleged that the recommender system tends to recommend extremist content and conspiracy theories, as such videos are especially likely to capture and keep users’ attention. To date, the problem of radicalization via the YouTube recommender system has been a matter of speculation. The current study represents the first systematic, pre-registered attempt to establish whether and to what extent the recommender system tends to promote such content. We begin by contextualizing our study in the framework of technological seduction. Next, we explain our methodology. After that, we present our results, which are consistent with the radicalization hypothesis. Finally, we discuss our findings, as well as directions for future research and recommendations for users, industry, and policy-makers. (shrink)

In this paper, we consider three arguments for the irrelevance of the doctrine of double effect in end-of-life decision making. The third argument is our own and, to that extent, we seek to defend it. The first argument is that end-of-life decisions do not in fact shorten lives and that therefore there is no need for the doctrine in justification of these decisions. We reject this argument; some end-of-life decisions clearly shorten lives. The second is that the doctrine of double (...) effect is not recognized in UK law ; therefore, clinicians cannot use it as the basis for justification of their decisions. Against this we suggest that while the doctrine might have dubious legal grounds, it could be of relevance in some ways, e.g. in marking the boundary between acceptable and unacceptable practice in relation to the clinician's duty to relieve pain and suffering. The third is that the doctrine is irrelevant because it requires there to be a bad effect that needs justification. This is not the case in end-of-life care for patients diagnosed as dying. Here, bringing about a satisfactory dying process for a patient is a good effect, not a bad one. What matters is that patients die without pain and suffering. This marks a crucial departure from the double-effect doctrine; if the patient's death is not a bad effect then the doctrine is clearly irrelevant. A diagnosis of dying allows clinicians to focus on good dying and not to worry about whether their intervention affects the time of death. For a patient diagnosed as dying, time of death is rarely important. In our conclusion we suggest that acceptance of our argument might be problematic for opponents of physician-assisted death. We suggest one way in which these opponents might argue for a distinction between such practice and palliative care; this relies on the double-effect doctrine's distinction between foresight and intention. (shrink)

A decade ago, we reviewed the field of clinical ethics; assessed its progress in research, education, and ethics committees and consultation; and made predictions about the future of the field. In this article, we revisit clinical ethics to examine our earlier observations, highlight key developments, and discuss remaining challenges for clinical ethics, including the need to develop a global perspective on clinical ethics problems.

Since the 1960s, many artists have incorporated ecological concerns into their work, an endeavor that has required new strategies in art-making. To explore recent American manifestations of these interests, the David and Alfred Smart Museum commissioned new projects from artists Mark Dion, Peter Fend, and Dan Peterman, each focusing on interrelationships between particular organisms—human beings-and a specific group of sites—a museum building, a river landscape, and a university campus. The results, exhibited at the Smart Museum during the summer (...) of 2000, evoke the varied scales, from the microscopic to the global, at which human actions affect the environment. This catalog documents each of the artists' projects through an array of images and words: Smart Museum Associate Curator Stephanie Smith provides an introduction and brief overviews of the three projects, each of the artists contribute statements, and photographers Susan Anderson and Tom van Eynde document—in over 100 images—the processes and projects that comprise the exhibition. (shrink)

We defend the reliability of Hurlburt's Descriptive Experi-ence Sampling method against some of Schwitzgebel's attacks. But we agree with Schwitzgebel that the method could be used much more widely than it has been, helping to answer questions about the nature and structure of consciousness in addition to cataloguing the latter's contents. We sketch a number of potential lines of further enquiry.

The medium surrounding cells either in culture or in tissues contains a chemical mix varying with cell state. As solutes move in and out of the cytoplasmic compartment they set up characteristic signatures in the cellular boundary layers. These layers are complex physical and chemical environments the profiles of which reflect cell physiology and provide conduits for intercellular messaging. Here we review some of the most relevant characteristics of the extracellular/intercellular space. Our initial focus is primarily on cultured cells but (...) we extend our consideration to the far more complex environment of tissues, and discuss how chemical signatures in the boundary layer can or may affect cell function. Critical to the entire essay are the methods used, or being developed, to monitor chemical profiles in the boundary layers. We review recent developments in ultramicro electrochemical sensors and tailored optical reporters suitable for the task in hand. (shrink)

Ran is one of the most abundant and best conserved of the small GTP binding and hydrolyzing proteins of eukaryotes. It is located predominantly in cell nuclei. Ran is a member of the Ras family of GTPases, which includes the Ras and Ras‐like proteins that regulate cell growth and division, the Rho and Rac proteins that regulate cytoskeletal organization and the Rab proteins that regulate vesicular sorting. Ran differs most obviously from other members of the Ras family in both its (...) nuclear localization, and its lack of sites required for post‐translational lipid modification. Ran is, however, similar to other Ras family members in requiring a specific guanine nucleotide exchange factor (GEF) and a specific GTPase activating protein (GAP) as stimulators of overall GTPase activity. In this review, the multiple cellular functions of Ran are evaluated with respect to its known biochemistry and molecular interactions. (shrink)

Why does the air-target and its associated practices matter? This special section is about the politics, practices and ethics surrounding the target and efforts to subvert or circumvent them. Since Eyal Weizman’s groundbreaking essay on the ‘politics of verticality’ in 2002, there have been numerous attempts to critically open up the aerial gaze, but rarely have they come together for sustained analysis and critique, to explore the implications of the air-target’s techniques, processes, visual cultures and aesthetics for politics and life (...) itself. This special section brings together leading international experts in order to open out a fuller and more complete analysis of the kinds of tensions of verticality that lie at the heart of today’s warfare, security and politics. This introduction outlines three dominant problematics of the air-target, which the articles in the section will go on to explore in more detail. (shrink)

The scientific, ethical, and policy issues raised by research involving the engraftment of human neural stem cells into the brains of nonhuman primates are explored by an interdisciplinary working group in this Policy Forum. The authors consider the possibility that this research might alter the cognitive capacities of recipient great apes and monkeys, with potential significance for their moral status.

This systematic introduction to Buddhist ethics is aimed at anyone interested in Buddhism, including students, scholars and general readers. Peter Harvey is the author of the acclaimed Introduction to Buddhism, and his new book is written in a clear style, assuming no prior knowledge. At the same time it develops a careful, probing analysis of the nature and practical dynamics of Buddhist ethics in both its unifying themes and in the particularities of different Buddhist traditions. The book applies Buddhist (...) ethics to a range of issues of contemporary concern: humanity's relationship with the rest of nature; economics; war and peace; euthanasia; abortion; the status of women; and homosexuality. Professor Harvey draws on texts of the main Buddhist traditions, and on historical and contemporary accounts of the behaviour of Buddhists, to describe existing Buddhist ethics, to assess different views within it, and to extend its application into new areas. (shrink)

The past hypothesis is that the entropy of the universe was very low in the distant past. It is put forward to explain the entropic arrow of time but it has been suggested. The emperor’s new mind. London:Vintage Books; Penrose, R.. Annals of the New York Academy of Sciences, 571, 249–264; Price, H.. In S. F. Savitt, Times’s arrows today. Cambridge: Cambridge University Press; Price, H.. Time’s arrow and Archimedes’ point. Oxford: Oxford University Press; Price, H.. In C. Hitchcock, Contemporary (...) debates in philosophy of science. Oxford: Blackwell]) that it is itself in need of explanation. It has also been suggested that cosmic inflation could provide the explanation, but Price raises a serious objection to this suggestion, which has otherwise received very little attention in the philosophical literature. Price points out that the standard inflationary explanation involves a double standard: although the evolution of the universe described by the inflationary model seems natural from the standard temporal perspective it looks highly unnatural from the reversed temporal perspective. The main purpose of this paper is to propose a novel form of the inflationary explanation that avoids this objection. It is argued that the inflationary model would not involve a double standard if we construct the model with a global “boundary” condition instead of a conventional boundary condition: if we assume that the universe is as generic as possible overall, rather than as generic as possible at some given point as is assumed in the standard inflationary model. This novel form of the inflationary explanation is then compared with Price’s 1996 preferred explanation, a version of the so-called “Weyl hypothesis”. (shrink)

Michael A. PetersBeijing Normal UniversityMy deepest condolences to Pepe, Dom and Marcus and to Jim’s grandchildren. Tina and I spent a lot of time at the Marshall family home, often attending dinn...

Barley aleurone cells have long served as a model system for studying the regulation of gene expression in plants. In this review we survey what is known about hormone‐regulated gene expression in aleurone cells. We also describe the effects of heat stress on gene expression in this system, and speculate how the aleurone cell prioritizes its response between hormone‐induced and environment‐induced programs of gene expression.